For an oocyte being All set for fertilization and growth into an embryo, the right list of genes needs to be turned on. Namekawa suspected that this pre-programming with the oocyte genome comes about in various levels — the first 1 starting around the time a female is born. He thought that chromatin remodeling proteins did Considerably of this perform, by shifting spools close to.
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This may support explain why more mature Ladies usually tend to bear kids with chromosomal Diseases like Down Syndrome, during which an extra copy of chromosome 21 finds its way into an oocyte — and later on, an embryo.
Munakata and Namekawa will Review mice with standard and mutated variations in the chromatin remodeler. As being the mice expand and mature, they will notice whether the existence or absence of this protein triggers discrepancies inside the arrangement of DNA spools in the animals’ oocytes. And they're going to check whether or not this, consequently, alters the pattern of gene expression after a while.
Each includes a mass of thread-like DNA — akin to four hundred miles of yarn. To help keep it from devolving into a tangle, the DNA is wrapped all-around a number of protein spools, referred to as nucleosomes.
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